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Br J Cancer. 2005 Feb 14;92(3):430-3.

Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis.

Author information

1
Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. arenehan@picr.man.ac.uk

Abstract

A meta-analysis of six randomised trials demonstrated that intensive followup in colorectal cancer was associated with an absolute reduction in all-cause 5-year mortality of 10% (95% confidence interval (CI): 4-16)--however, only two percent (95% CI: 0-5) was attributable to cure from salvage re-operations. We postulate that other factors, such as increased psychological well-being and/or altered lifestyle, and/or improved treatment of coincidental disease may contribute to the remaining lives saved, and form important future research questions.

PMID:
15685236
PMCID:
PMC2362076
DOI:
10.1038/sj.bjc.6602369
[Indexed for MEDLINE]
Free PMC Article

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