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Br J Pharmacol. 2005 Apr;144(7):887-8.

Postnatal consequences of prenatal cocaine exposure and myocardial apoptosis: does cocaine in utero imperil the adult heart?

Author information

1
Departments of Medicine, Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada. qfeng@uwo.ca

Abstract

Cocaine use is common among pregnant women with a history of substance abuse, and has been shown to cause abnormalities in the heart during fetal and postnatal development. However, mechanisms underlying the detrimental effects of cocaine on the developing heart are not fully understood. In this issue, Bae and Zhang show that prenatal cocaine exposure increases the susceptibility of the postnatal heart to ischemia and reperfusion injury. Their results suggest that myocardial apoptosis induced by cocaine during fetal development may represent one of the mechanisms by which prenatal cocaine exposure exerts its long-term, deleterious consequences on postnatal cardiac function.

PMID:
15685202
PMCID:
PMC1576081
DOI:
10.1038/sj.bjp.0706130
[Indexed for MEDLINE]
Free PMC Article
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