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Nat Med. 2005 Feb;11(2):127-9. Epub 2005 Jan 30.

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

Author information

1
The Netherlands Cancer Institute, Division of Experimental Therapy, Amsterdam, The Netherlands.

Abstract

Contamination of milk with drugs, pesticides and other xenotoxins can pose a major health risk to breast-fed infants and dairy consumers. Here we show that the multidrug transporter BCRP (encoded by ABCG2) is strongly induced in the mammary gland of mice, cows and humans during lactation and that it is responsible for the active secretion of clinically and toxicologically important substrates such as the dietary carcinogen PhIP, the anticancer drug topotecan and the antiulcerative cimetidine into mouse milk.

PMID:
15685169
DOI:
10.1038/nm1186
[Indexed for MEDLINE]
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