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Chem Pharm Bull (Tokyo). 2005 Feb;53(2):229-31.

A new and known cytotoxic aryltetralin-type lignans from stems of Bursera graveolens.

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  • 1Faculty of Pharmaceutical Sciences, Setsunan University, Osaka Japan.


A new 4alpha-aryltetralin-type lignan called burseranin (1) and a known analogous lignan picropolygamain (2) were isolated along with known triterpenes, lupeol and epi-lupeol from the methanol extract of stems of Bursera graveolens, which showed a remarkable inhibitory activity against human HT1080 fibrosarcoma cells. The whole structure of 1 was established based on combined spectral studies and the absolute structure for 2 was first confirmed by CD spectral evidence. In addition, cytotoxic activities of the stem (methanol) extract and its components are evaluated in this paper.

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