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Science. 2005 Feb 25;307(5713):1324-8. Epub 2005 Jan 27.

Control of excitatory and inhibitory synapse formation by neuroligins.

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1
Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

Erratum in

  • Science. 2005 Jun 3;308(5727):1413.

Abstract

The normal function of neural networks depends on a delicate balance between excitatory and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional signaling between pre- and postsynaptic cells. We demonstrate that members of the Neuroligin family promote postsynaptic differentiation in cultured rat hippocampal neurons. Down-regulation of neuroligin isoform expression by RNA interference results in a loss of excitatory and inhibitory synapses. Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons.

PMID:
15681343
DOI:
10.1126/science.1107470
[Indexed for MEDLINE]
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