Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 2005 Feb 7;579(4):955-8.

On the structural basis of peptide-bond formation and antibiotic resistance from atomic structures of the large ribosomal subunit.

Author information

1
Department of Molecular Biophysics and Biochemistry, Yale University, and Howard Hughes Medical Institute, P.O. Box 208114, New Haven, CT 06520-8114, USA. eatherton@csb.yale.edu

Abstract

The atomic structures of the large ribosomal subunit from Haloarcula marismortui and its complexes with substrates and antibiotics have provided insights into the way the 3000 nucleotide 23S rRNA folds into a compact, specific structure and interacts with 27 ribosomal proteins as well as the structural basis of the peptidyl transferase reaction and its inhibition by antibiotics. The structure shows that the ribosome is indeed a ribozyme.

PMID:
15680981
DOI:
10.1016/j.febslet.2004.11.053
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center