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FEBS Lett. 2005 Feb 7;579(4):904-8.

The mammalian Mediator complex.

Author information

1
Stowers Institute for Medical Research, Kansas City, MO 64110, USA. jlc@stowers-institute.org

Abstract

The multiprotein Mediator (Med) complex is an evolutionarily conserved transcriptional regulator that plays important roles in activation and repression of RNA polymerase II transcription. Prior studies identified a set of more than twenty distinct polypeptides that compose the Saccharomyces cerevisiae Mediator. Here we discuss efforts to characterize the subunit composition and associated activities of the mammalian Med complex.

PMID:
15680972
DOI:
10.1016/j.febslet.2004.11.031
[Indexed for MEDLINE]
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