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J Nat Prod. 2005 Jan;68(1):83-5.

Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species.

Author information

1
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, A-8010 Graz, Austria.

Abstract

Fifteen stilbenoids and two alkaloids from Stemona collinsae, S. tuberosa, and S. peirrei were tested alongside the commercially available stilbenoids resveratrol and pinosylvin for inhibition of leukotriene formation in an ex vivo test system based on activated human neutrophilic granulocytes. The stilbenoids resveratrol (1), pinosylvin (2), dihydropinosylvin (3), stilbostemin A (4), stilbostemin B (5), stilbostemin D (6), stilbostemin F (7), stilbostemin G (8), stemofuran B (9), stemofuran C (10), stemofuran D (11), stemofuran G (12), stemofuran J (13), stemanthrene A (14), stemanthrene B (15), stemanthrene C (16), and stemanthrene D (17) showed structure-dependent activities with IC(50) values ranging from 3.7 to >50 microM. The alkaloids tuberostemonine (18) and neotuberostemonine (19) were inactive at a concentration of 50 microM.

PMID:
15679323
DOI:
10.1021/np0497043
[Indexed for MEDLINE]

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