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J Nat Prod. 2005 Jan;68(1):56-9.

Four new neuroprotective dihydropyranocoumarins from Angelica gigas.

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1
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, San 56-1, Sillim-Dong, Gwanak-Gu, Seoul 151-742, Korea.

Abstract

Four new dihydropyranocoumarins were isolated from Angelica gigas roots through neuroprotective activity-guided isolation and were characterized as decursinol derivatives 4"-hydroxytigloyldecursinol (1), 4"-hydroxydecursin (2), (2"S,3"S)-epoxyangeloyldecursinol (3), and (2"R,3"R)-epoxyangeloyldecursinol (4), respectively. All four new dihydropyranocoumarins and major coumarin derivatives of A. gigas, decursinol and decursin, exhibited significant protective activity against glutamate-induced neurotoxicity when added to primary cultures of rat cortical cells at concentrations ranging from 0.1 to 10 microM.

PMID:
15679317
DOI:
10.1021/np049705v
[Indexed for MEDLINE]
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