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Magn Reson Med. 2005 Feb;53(2):275-81.

Chemical-shift-selective filter for the in vivo detection of J-coupled metabolites at 3T.

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1
Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology, Zurich, Switzerland.

Abstract

A chemical-shift-selective filter (CSSF) was applied to the detection of J-coupled metabolites in the human brain. This filter is an acquisition-based technique that requires the chemical shifts (CS's) of different metabolites, but not their whole multiplet structures, to be resolved. The sequence is based on the 2D constant-time spin-echo experiment, which yields pure CS spectra in the indirect dimension. Localization is achieved through point-resolved spectroscopy (PRESS). The method enables unequivocal detection of glutamate and myo-inositol, both in vitro and in vivo in the human brain, at 3T.

PMID:
15678545
DOI:
10.1002/mrm.20362
[Indexed for MEDLINE]
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