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HNO. 2005 Nov;53(11):940-4.

[Salivary duct carcinoma of the submandibular gland].

[Article in German]

Author information

1
Klinik und Poliklinik f├╝r Hals-, Nasen- und Ohrenheilkunde, Universit├Ątsklinikum Hamburg-Eppendorf. jaehne@uke.uni-hamburg.de

Abstract

BACKGROUND:

Salivary duct carcinoma (SDC) is a rare adenocarcinoma of the salivary glands which usually occurs in the parotid gland (approx. 80%), but is also found in the submandibular gland (approx. 12%) and the minor salivary glands. Due to the low incidence of this tumour-particularly in terms of involvement of the submandibular and minor salivary glands-only limited clinical data is available.

PATIENTS/METHOD:

In a retrospective investigation, follow-ups of six patients with a SDC of the submandibular gland were analysed and the surgical measures evaluated for their efficiency.

RESULTS:

At the time of diagnosis, varying tumor stages were present (2xT1, 3xT2, 1xT1). Initial lymph node metastasis was observed in four (66.6%) of the six patients. In all patients, the submandibular gland was resected and neck dissection performed, in two cases (33,3%) this was followed by radiotherapy. Four patients developed a life-threatening local recurrence. Only one patient developed distant metastasis. Two thirds of the patients died due to tumor-related disease after an average of 35.5 months.

CONCLUSION:

The clinical course of patients with SDC of the submandibular gland exhibits a high (66.6%) rate of local recurrence, crucial for the following clinical course. The treatment of these patients, therefore, must include radical tumor resection as well as tissue resection with a wide margin.

PMID:
15678343
DOI:
10.1007/s00106-004-1204-z
[Indexed for MEDLINE]
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