Format

Send to

Choose Destination
See comment in PubMed Commons below
Drug Discov Today. 2005 Jan 1;10(1):53-60.

High-throughput target discovery using cell-based genetics.

Author information

1
Athersys Inc., 3201 Carnegie Ave., Cleveland, OH 44115, USA.

Abstract

High-throughput target discovery requires robust disease models and the ability to rapidly survey the genome for function. In the post-genomics era, there has been a strong emphasis placed upon "gene-to-function" approaches that take advantage of the large amount of gene sequence information now available. Here, we advocate a return to "function-to-gene" approaches as a first step in target discovery (and validation), followed by hypothesis-driven research to validate new targets identified by their activity in cell-based disease models.

PMID:
15676299
DOI:
10.1016/S1359-6446(04)03303-3
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center