Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Investig Drugs. 2005 Jan;6(1):48-57.

Transient receptor potential ion channels as targets for the discovery of pain therapeutics.

Author information

1
Department of Biochemistry, Neurogen Corporation, Branford, CT 06405, USA. jkrause@nrgn.com

Abstract

A subset of transient receptor potential (TRP) channels exhibits activity that is highly sensitive to temperature changes and is expressed in sensory tissues, such as nociceptors and skin. Some of these thermosensitive TRP channels, such as TRPV1, TRPV4 and TRPA1, are activated or sensitized by molecules generated by inflammation and/or cell damage. TRPV1, also known as the capsaicin receptor, is particularly important in mediating hyperalgesic responses in inflammatory pain states, as demonstrated by research in knockout animals and with small-molecule antagonists. It is anticipated that TRPV1 antagonists, and perhaps antagonists at other thermosensitive TRP channels, will provide new therapeutic options with which to treat clinical pain.

PMID:
15675603
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center