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ScientificWorldJournal. 2005 Jan 14;5:5-8.

Combined effects of estrogen and mechanical loading on anterior cruciate ligament fibroblast biosynthesis.

Author information

  • 1Sports Medicine Research Center, Department of Orthopedic Surgery, Baylor College of Medicine, 6550 Fannin Street, Suite 451, Houston, TX 77030, USA.

Abstract

For some time, estrogen has been suspected to play a negative role in anterior cruciate ligament (ACL) fibroblast biosynthesis; however, reports on this issue have been controversial. In a recent study, our group demonstrated a negative combined effect of estrogen and mechanical loading on the gene expression of major extracellular matrix component molecules in ACL fibroblasts.

PMID:
15674443
DOI:
10.1100/tsw.2005.6
[PubMed - indexed for MEDLINE]
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