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J Perinatol. 2005 May;25(5):299-303.

Incidence and clinical manifestations of breast milk-acquired Cytomegalovirus infection in low birth weight infants.

Author information

1
Pediatric Infectious Disease Consultation Service, Ha'Emek Medical Center, Afula, Rappaport School of Medicine, Haifa, Israel.

Abstract

OBJECTIVES:

To determine the incidence and clinical manifestations of human breast milk (HMB)-associated acquired cytomegalovirus (CMV) infection in small premature infants.

STUDY DESIGN:

A prospective study of premature infants born at or prior to 32 weeks gestation, and or infants weighing 1500 g or less at birth. The babies were divided into two groups: Group 1 included babies of CMV seropositive mothers who received HBM throughout the study period. Group 2 included babies of seronegative mothers or babies that did not receive HBM at all. Urine sample were obtained once weekly from birth until the age of 8 weeks or until discharge and were tested for the presence of CMV-DNA by PCR.

RESULTS:

Four of 70 infants from group 1 (5.7%, 95% CI, 0 to 11%) acquired CMV infection between the ages of 3 and 7 weeks as compared to none of 26 babies in group 2. Only one infected baby had severe CMV disease with complete recovery.

CONCLUSION:

The relative incidence of HBM-associated CMV infection and the severity of HBM-associated CMV disease in premature infants are low.

PMID:
15674408
DOI:
10.1038/sj.jp.7211255
[Indexed for MEDLINE]

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