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Antimicrob Agents Chemother. 2005 Feb;49(2):830-2.

Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice.

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1
Division of Infectious Diseases, Harbor-UCLA Research and Education Institute, St. John's Cardiovascular Research Center, 1124 West Carson St., Torrance, CA 90502, USA.

Abstract

We studied the combination of amphotericin B lipid complex (ABLC) and caspofungin in mice with disseminated Rhizopus oryzae. Combination therapy improved survival compared to that of mice given monotherapy and that of untreated controls (P < 0.05) but did not improve organ clearance. In addition, prophylactic combination therapy was not more effective than prophylactic ABLC alone.

PMID:
15673781
PMCID:
PMC547325
DOI:
10.1128/AAC.49.2.830-832.2005
[Indexed for MEDLINE]
Free PMC Article
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