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Viral Immunol. 2004;17(4):481-97.

Hantaviruses: immunology, treatment, and prevention.

Author information

1
Laboratory of Clinical Virology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.

Abstract

Hantaviruses are rodent-borne bunyaviruses that are associated with two main clinical diseases in humans: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. It has been suggested that host-related immune mechanisms rather than direct viral cytopathology may be responsible for the principal abnormality (vascular dysfunction) in these syndromes. This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.

PMID:
15671746
DOI:
10.1089/vim.2004.17.481
[Indexed for MEDLINE]

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