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Hum Antibodies. 2004;13(4):105-10.

Human monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assembly.

Author information

  • 1Avanir Pharmaceuticals, Antibody Technology, 11388 Sorrento Valley Rd, San Diego, CA 92121, USA. fwang@avanir.com

Abstract

A panel of human anti-anthrax protective antigen IgG1 monoclonal antibodies were evaluated to determine the mechanism of toxin neutralization. AVP-22G12, AVP-1C6 and AVP-21D9 bound to the protective antigen with picomolar affinities to distinct non-overlapping linear epitopes. Two of the antibodies neutralized the anthrax toxin by completely inhibiting the protective antigen oligomer assembly process in vitro.

PMID:
15671576
[PubMed - indexed for MEDLINE]
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