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Biochem Biophys Res Commun. 2005 Mar 4;328(1):57-62.

The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse.

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  • 1Department of Cell Biology, Department of Pharmacokinetics and Drug Delivery, Department of Pathology and Laboratory Medicine, [corrected] Medical Biology Section, Groningen University Institute for Drug Exploration (GUIDE), The Netherlands.

Erratum in

  • Biochem Biophys Res Commun. 2005 May 20;330(4):1320.

Abstract

We evaluated the role of apolipoprotein E (apoE) in the clearance of neutral and negatively charged liposomes by hepatocytes in apoE-deficient mice. Negatively charged liposomes were cleared at identical rates in apoE-deficient and wild-type mice; neutral liposomes were cleared at a 3.6-fold slower rate in apoE-deficient mice. ApoE deficiency did not affect hepatic uptake of negatively charged liposomes but lowered that of neutral liposomes >5-fold. Hepatocyte uptake of neutral liposomes was reduced >20-fold in apoE-deficient mice; that of negatively charged liposomes remained unchanged. We conclude that uptake of neutral liposomes by hepatocytes is nearly exclusively apoE-mediated.

PMID:
15670750
DOI:
10.1016/j.bbrc.2004.12.137
[PubMed - indexed for MEDLINE]
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