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Biochem Soc Trans. 2005 Feb;33(Pt 1):42-6.

Formate and its role in hydrogen production in Escherichia coli.

Author information

1
Department of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK. gary.sawers@bbsrc.ac.uk

Abstract

The production of dihydrogen by Escherichia coli and other members of the Enterobacteriaceae is one of the classic features of mixed-acid fermentation. Synthesis of the multicomponent, membrane-associated FHL (formate hydrogenlyase) enzyme complex, which disproportionates formate into CO(2) and H(2), has an absolute requirement for formate. Formate, therefore, represents a signature molecule in the fermenting E. coli cell and factors that determine formate metabolism control FHL synthesis and consequently dihydrogen evolution.

PMID:
15667260
DOI:
10.1042/BST0330042
[Indexed for MEDLINE]

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