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Bioorg Med Chem Lett. 2005 Feb 1;15(3):751-4.

Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.

Author information

1
Celltech R and D, Granta Park, Great Abington, Cambridge CB1 6GS, UK.

Abstract

The development of a series of novel quinazolinethiones and quinazolinediones as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II and in vitro inhibitory value for PBMC proliferation are discussed.

PMID:
15664851
DOI:
10.1016/j.bmcl.2004.11.015
[Indexed for MEDLINE]

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