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Mol Cell. 2005 Jan 21;17(2):166-7.

Domain swapping and retroviral assembly.

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  • 1Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.

Abstract

The structure of a mammalian SCAN domain has been recently reported. The molecule is a structural homolog of the HIV-1 capsid protein and forms a domain-swapped dimer in solution. The authors propose a similar domain-swapping event facilitates HIV-1 assembly, providing a new model for protein-protein interactions underlying viral particle formation.

PMID:
15664185
DOI:
10.1016/j.molcel.2005.01.002
[PubMed - indexed for MEDLINE]
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