Format

Send to

Choose Destination
Cancer Biol Ther. 2004 Dec;3(12):1200-7. Epub 2004 Dec 15.

Cell cycle regulation and hepatocarcinogenesis.

Author information

1
Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA. greenbal@mail.med.upenn.edu

Abstract

Hepatocellular carcinoma (HCC) develops on a background of chronic hepatitis or cirrhosis. The slow progression of this disease has facilitated the identification of discrete pathologic stages. Increased rates of hepatocyte proliferation in preneoplastic nodules is an early event in the progression of HCC. Increased cell turnover results in the selection of monoclonal hepatocyte populations that subsequently undergo genomic alterations that lead to the development of HCC. The heterogeneous nature of genomic alterations identified in tumors from patients with HCC has impeded the identification of regulatory pathways whose disruption are critical for tumor initiation. However, several regulatory networks important for liver cell proliferation have been characterized using the partial hepatectomy model, an in vivo model of liver cell cycle progression, and are likely relevant to the pathogenesis of hepatocellular carcinoma.

PMID:
15662121
DOI:
10.4161/cbt.3.12.1392
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center