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DNA Repair (Amst). 2005 Mar 2;4(3):309-14.

The role of SMC proteins in the responses to DNA damage.

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Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK.


The SMC proteins form the cores of three protein complexes in eukaryotes, cohesin, condensin and the Smc5-6 complex. Cohesin holds sister chromatids together after DNA replication and is involved in both the repair of double-strand breaks by homologous recombination and the intra-S-phase checkpoint. Condensin assists in the condensation of chromosomes at mitosis and also has a role in checkpoint control pathways. The Smc5-6 complex is involved in a variety of DNA repair and damage response pathways by as yet unknown mechanisms, but is also associated with repair by homologous recombination.

[Indexed for MEDLINE]

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