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Curr Opin Cell Biol. 2005 Feb;17(1):3-8.

RNAi as a tool to study cell biology: building the genome-phenome bridge.

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Center for Comparative Functional Genomics, Department of Biology, New York University, 1009 Silver Center, 100 Washington Sq E, New York, New York 10003, USA.


In the few short years since its discovery, RNA interference (RNAi) has revolutionized the functional analysis of genomes: both technical and conceptual approaches to the investigation of gene function are being transformed as a result of this new technology. Genome-scale RNAi analyses have already been performed in the model organisms Caenorhabditis elegans (in vivo) and Drosophila melanogaster (in cell lines), ushering in a new era of RNAi-based approaches to probing the inner workings of the cell. The transformation of complex phenotypic data into mineable 'digitized' formats is fostering the emergence of a new area of bioinformatics related to the phenome.

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