Format

Send to

Choose Destination
Trends Biotechnol. 2005 Feb;23(2):59-64.

Papa's got a brand new tag: advances in identification of proteases and their substrates.

Author information

1
Program in Chemistry and Chemical Biology, Department of Pharmaceutical Chemistry, The University of California, San Francisco, California 94143, USA.

Abstract

Characterization of proteolytic enzymes and their substrates presents a formidable challenge in the context of biological systems. Despite the fact that an estimated 2% of the human genome codes for proteases, only a small fraction of these enzymes have well-characterized functions. Much of the difficulty in understanding protease biology is a direct result of the complexity of regulation, localization and activation exhibited by this class of enzymes. Here, we focus on several recently developed techniques representing crucial advances toward identification of proteases and their natural substrates.

PMID:
15661339
DOI:
10.1016/j.tibtech.2004.12.010
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center