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Virology. 2005 Feb 5;332(1):16-9.

Decreased perforin and granzyme B expression in senescent HIV-1-specific cytotoxic T lymphocytes.

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1
Department of Medicine (Division of Infectious Diseases), UCLA Medical Center, Los Angeles, CA 90095-1688, USA. oyang@mednet.ucla.edu

Abstract

Cytotoxic T lymphocyte (CTL) senescence may be an important mechanism of immune failure in HIV-1 infection. We find that senescence of HIV-1-specific CTL clones causes loss of killing activity, preventable by transduction with telomerase. Furthermore, senescence is associated with reduced expression of the effector molecules granzyme and perforin, suggesting CTL "exhaustion" can result in hypofunction. These results agree with other studies showing that HIV-1-specific CTL exhibit abnormal phenotypes in vivo, and suggest the possibility that chronic turnover is an important mechanism of antiviral failure in HIV-1 infection.

PMID:
15661136
DOI:
10.1016/j.virol.2004.11.028
[Indexed for MEDLINE]
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