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Nat Rev Cancer. 2005 Feb;5(2):113-25.

Nature and nurture - lessons from chemical carcinogenesis.

Author information

1
Massachusetts Institute of Technology, Center for Cancer Research, 77 Massachusetts Avenue, E17-132, Cambridge, Massachusetts 02319, USA. luch@mit.edu

Abstract

The roles of genetic constitution versus environmental factors in cancer development have been a matter of debate even long before the discovery of 'oncogenes'. Evidence from epidemiological, occupational and migration studies has consistently pointed to environmental factors as the major contributing factors to cancer, so it seems reasonable to discuss the importance of chemical carcinogenesis in the present 'age of cancer genetics'.

PMID:
15660110
DOI:
10.1038/nrc1546
[Indexed for MEDLINE]

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