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Curr Opin Pediatr. 2005 Feb;17(1):88-92.

Rotavirus vaccines: an update.

Author information

  • 1Division of Pediatric Infectious Diseases, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island 02903, USA. pdennehy@lifespan.org

Abstract

PURPOSE OF REVIEW:

Rotavirus infection is the most common cause of severe diarrhea disease in infants and young children worldwide and has a major global impact on childhood morbidity and mortality. Vaccination is the only control measure likely to have a significant impact on the incidence of severe dehydrating rotavirus disease.

RECENT FINDINGS:

Rotavirus disease prevention efforts suffered a great setback in 1999 with the withdrawal of the RRV-TV vaccine less than a year after its introduction. Several new rotavirus vaccine candidates have now been developed and are undergoing clinical trials.

SUMMARY:

New safe and effective rotavirus vaccines offer the best hope of reducing the toll of acute rotavirus gastroenteritis in both developed and developing countries.

PMID:
15659970
[PubMed - indexed for MEDLINE]
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