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Semin Cell Dev Biol. 2005 Feb;16(1):83-94. Epub 2004 Dec 15.

The roles of GATA-4, -5 and -6 in vertebrate heart development.

Author information

1
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS.

Abstract

The transcription factors GATA-4, -5 and -6 are expressed very early in heart tissue. Essential GATA sites have been detected in several cardiac genes and the cardiac GATA factors interact with a wide variety of cofactors which synergistically increase gene expression. These multi-protein transcriptional complexes confer promoter-specificity on the GATA factors and also on the more broadly expressed cofactors. Here we summarise the data on these interactions and represent the conclusions as a GATA factor-based genetic regulatory network for the heart. Of the three cardiac GATAs, GATA-4 is by far the most extensively studied, however, loss-of-function data question its presumed dominance during heart development as opposed to hypertrophy.

PMID:
15659343
DOI:
10.1016/j.semcdb.2004.10.003
[Indexed for MEDLINE]

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