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Semin Cell Dev Biol. 2005 Feb;16(1):39-47. Epub 2004 Dec 10.

The implications of structured 5' untranslated regions on translation and disease.

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Department of Biochemistry, University of Leicester, University Rd, Leicester LE17RH, UK.


Translational control is a key step in eukaryotic gene expression. The majority of translational control occurs at the level of initiation, thus implicating the 5' untranslated region as a major site of translational regulation. Many growth-related mRNAs have atypical 5' UTRs, which are often long and GC-rich. Such features promote formation of stable secondary structure, and many mRNAs encoding proteins involved in cell growth, proliferation and apoptosis have structured 5' UTRs, which in many cases harbour internal ribosome entry sites (IRESs) and upstream open-reading frames (uORFs). In this review we discuss how secondary structural elements in the 5' UTR can regulate translation and how mutations that perturb these secondary structural elements can have implications for disease and tumourigenesis.

[Indexed for MEDLINE]

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