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Nat Rev Mol Cell Biol. 2005 Feb;6(2):127-38.

Assembly and function of RNA silencing complexes.

Author information

1
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, Illinois 60208-3500, USA. erik@northwestern.edu

Abstract

In the RNA-interference pathway, double-stranded RNA induces sequence-specific mRNA degradation through the action of the RNA-induced silencing complex (RISC). Recent work has provided our first glimpses of the RISC-assembly pathway and uncovered the biochemical roles of critical RISC components. These advances have taken our mechanistic understanding of RNA interference to a new level and promise to improve our ability to exploit this biological process for use in experimental biology and medicine.

PMID:
15654322
DOI:
10.1038/nrm1568
[Indexed for MEDLINE]

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