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J Biol Chem. 2005 Mar 25;280(12):11583-9. Epub 2005 Jan 14.

Androgen receptor activation by G(s) signaling in prostate cancer cells.

Author information

1
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.

Abstract

The androgen receptor (AR) is activated in prostate cancer patients undergoing androgen ablative therapy and mediates growth of androgen-insensitive prostate cancer cells, suggesting it is activated by nonandrogenic factors. We demonstrate that activated alpha subunit of heterotrimeric guanine nucleotide-binding G(s) protein activates the AR in prostate cancer cells and also synergizes with low concentration of androgen to more fully activate the AR. The G alpha(s) activates protein kinase A, which is required for the nuclear partition and activation of AR. These data suggest a role for G alpha(s) and PKA in the transactivation of AR in prostate cancer cells under the environment of reduced androgen levels.

PMID:
15653681
DOI:
10.1074/jbc.M414423200
[Indexed for MEDLINE]
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