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Trends Biochem Sci. 2005 Jan;30(1):43-52.

Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation.

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1
Laboratory of Medical Chemistry and Human Genetics, CHU, Sart-Tilman, Center for Biomedical Integrated Genoproteomics, University of Liege, Belgium.

Abstract

Nuclear factor-kappaB (NF-kappaB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. Activation of NF-kappaB mainly occurs via IkappaB kinase (IKK)-mediated phosphorylation of inhibitory molecules, including IkappaBalpha. Optimal induction of NF-kappaB target genes also requires phosphorylation of NF-kappaB proteins, such as p65, within their transactivation domain by a variety of kinases in response to distinct stimuli. Whether, and how, phosphorylation modulates the function of other NF-kappaB and IkappaB proteins, such as B-cell lymphoma 3, remains unclear. The identification and characterization of all the kinases known to phosphorylate NF-kappaB and IkappaB proteins are described here. Because deregulation of NF-kappaB and IkappaB phosphorylations is a hallmark of chronic inflammatory diseases and cancer, newly designed drugs targeting these constitutively activated signalling pathways represent promising therapeutic tools.

PMID:
15653325
DOI:
10.1016/j.tibs.2004.11.009
[Indexed for MEDLINE]
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