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J Carcinog. 2005 Jan 15;4(1):1.

Estrogen, mitochondria, and growth of cancer and non-cancer cells.

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Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294-0022 USA.


In this review, we discuss estrogen actions on mitochondrial function and the possible implications on cell growth. Mitochondria are important targets of estrogen action. Therefore, an in-depth analysis of interaction between estrogen and mitochondria; and mitochondrial signaling to nucleus are pertinent to the development of new therapy strategies for the treatment of estrogen-dependent diseases related to mitochondrial disorders, including cancer.

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