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Ann N Y Acad Sci. 2004 Dec;1028:351-60.

CXC chemokines: angiogenesis, immunoangiostasis, and metastases in lung cancer.

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1
Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, 900 Veteran Avenue, 14-154 Warren Hall, Los Angeles, CA 90024-1922, USA. rstrieter@mednet.ucla.edu

Abstract

CXC chemokines have been found to be important in the regulation of angiogenesis and tumor-related immunity, and in promoting organ-specific metastases. This review highlights the importance of CXC chemokine ligands and receptors in mediating non-small cell lung cancer tumor-associated angiogenesis, "immunoangiostasis," and organ-specific metastases. These findings may ultimately lead to clinical strategies to target CXC chemokines in non-small cell lung cancer.

PMID:
15650260
DOI:
10.1196/annals.1322.041
[Indexed for MEDLINE]
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