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J Virol. 2005 Feb;79(3):1966-9.

Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus.

Author information

1
Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden.

Abstract

Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.

PMID:
15650225
PMCID:
PMC544093
DOI:
10.1128/JVI.79.3.1966-1969.2005
[Indexed for MEDLINE]
Free PMC Article

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