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J Antimicrob Chemother. 2005 Feb;55(2):135-8. Epub 2005 Jan 13.

Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action.

Author information

1
Rega Institute for Medical Research, K. U. Leuven, B-3000 Leuven, Belgium. jan.balzarini@rega.kuleuven.ac.be

Abstract

Pyridine N-oxide derivatives represent a new class of anti-HIV compounds, for which some members exclusively act through inhibition of HIV-1 reverse transcriptase and thus characteristically behave as non-nucleoside reverse transcriptase inhibitors. Other members act, additionally or alternatively, at a post-integrational event in the replication cycle of HIV, that is, at the level of HIV gene expression. Repeated administration of one of the prototype compounds (JPL-32) to DBA/2 and hu-PBMC-SCID mice demonstrated, in the absence of any acute toxicity, protective activity against HIV-induced destruction of CD4 human T lymphocytes.

PMID:
15650002
DOI:
10.1093/jac/dkh530
[Indexed for MEDLINE]

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