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Trends Mol Med. 2005 Jan;11(1):17-22.

Medulloblastoma: developmental mechanisms out of control.

Author information

1
Institute of Clinical Pathology, University Hospital, Schmelzbergstrasse 12, 8091 Z├╝rich, Switzerland. silvia.marino@usz.ch

Abstract

Medulloblastoma, which is a highly aggressive central nervous system neoplasm, represents an intriguing example of how deregulated developmental mechanisms can lead to tumour development. Recent advances in the understanding of the role of Sonic Hedgehog, Wnt and Notch signalling pathways in the development of the cerebellum have shed new light on medulloblastoma pathogenesis.

PMID:
15649818
DOI:
10.1016/j.molmed.2004.11.008
[Indexed for MEDLINE]

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