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J Am Soc Nephrol. 2005 Feb;16(2):305-12. Epub 2005 Jan 12.

Caenorhabditis elegans as a model to study renal development and disease: sexy cilia.

Author information

1
School of Pharmacy, University of Wisconsin at Madison, 777 Highland Avenue, Madison, WI 53705, USA. mmbarr@pharmacy.wisc.edu

Abstract

The nematode Caenorhabditis elegans has no kidney per se, yet "the worm" has proved to be an excellent model to study renal-related issues, including tubulogenesis of the excretory canal, membrane transport and ion channel function, and human genetic diseases including autosomal dominant polycystic kidney disease (ADPKD). The goal of this review is to explain how C. elegans has provided insight into cilia development, cilia function, and human cystic kidney diseases.

PMID:
15647338
DOI:
10.1681/ASN.2004080645
[Indexed for MEDLINE]
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