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Chem Commun (Camb). 2005 Jan 21;(3):400-2. Epub 2004 Nov 30.

5-hydroxyuracil can form stable base pairs with all four bases in a DNA duplex.

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1
Department of Human Biological Chemistry & Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA.

Abstract

NMR studies, UV-monitored melting experiments, and ab initio calculations show that 5-hydroxyuracil, produced by the oxidative de-amination of cytosines by reactive oxygen species, can form stable base-pairs with dA, dG, dC and dT residues in a DNA duplex, providing a basis for the in-vivo incorporation of 5-hydroxyuracil during DNA replication.

PMID:
15645051
DOI:
10.1039/b414474k
[Indexed for MEDLINE]
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