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Ann Pharmacother. 2005 Feb;39(2):290-301. Epub 2005 Jan 11.

Sulfonamide cross-reactivity: fact or fiction?

Author information

1
Adult Internal Medicine Pharmacy Resident, Department of Pharmacy Services, Virginia Commonwealth University Medical Center-Medical College of Virginia (MCV) Campus, Richmond, VA 23298-0042, USA.

Erratum in

  • Ann Pharmacother. 2005 Jul-Aug;39(7-8):1373.

Abstract

OBJECTIVE:

To provide a critical and comprehensive review of the literature, specifically case reports and observational studies used to support the concept of cross-reactivity between sulfonylarylamines and non-sulfonylarylamines.

DATA SOURCES:

A list of medications was formulated from several different review articles. A MEDLINE/PubMed search was conducted (1966-March 2004) using the individual medications and the MeSH terms of drug hypersensitivity/etiology, sulfonamides/adverse effects, and/or cross-reaction.

STUDY SELECTION AND DATA EXTRACTION:

A critical review of the methodology and conclusions for each article found in the search was conducted. The manufacturer's package insert (MPI) for each drug was examined for a statement concerning possible cross-reactivity in patients with a sulfonamide allergy. If indicated, the manufacturers were contacted to obtain any clinical data supporting the statement.

DATA SYNTHESIS:

A total of 33 medications were identified. Seventeen (51.5%) of the MPIs contained statements of varying degrees concerning use in patients with a "sulfonamide" allergy; 21 case series, case reports, and other articles were found.

CONCLUSIONS:

After a thorough critique of the literature, it appears that the dogma of sulfonylarylamine cross-reactivity with non-sulfonylarylamines is not supported by the data. While many of the case reports on the surface support the concept of cross-reactivity, on closer examination the level of evidence in many of the cases does not conclusively support either a connection or an association between the observed cause and effect.

PMID:
15644481
DOI:
10.1345/aph.1E350
[Indexed for MEDLINE]

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