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EMBO Rep. 2005 Jan;6(1):22-7.

Postsynaptic scaffold proteins at non-synaptic sites. The role of postsynaptic scaffold proteins in motor-protein-receptor complexes.

Author information

1
Zentrum für Molekulare Neurobiologie Hamburg, ZMNH, Universität Hamburg, Falkenried 94, D-20251 Hamburg, Germany. matthias.kneussel@zmnh.uni-hamburg.de

Abstract

Synapse-associated proteins that are located at the postsynaptic density (PSD) have recently been shown to have a structural role at non-synaptic locations. Here, they act as adaptor proteins between neurotransmitter receptors and the microtubule- or microfilament-based motor-protein complexes that are responsible for transport to the PSD. The use of a common set of proteins that contain multiple domains for protein-protein interactions as both intracellular transport adaptors and synaptic scaffold proteins might contribute to the transport specificity and postsynaptic integration of receptors that underlie synapse formation and plasticity.

PMID:
15643447
PMCID:
PMC1299229
DOI:
10.1038/sj.embor.7400319
[Indexed for MEDLINE]
Free PMC Article

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