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Nat Neurosci. 2005 Feb;8(2):179-86. Epub 2005 Jan 9.

Endocytosis-dependent desensitization and protein synthesis-dependent resensitization in retinal growth cone adaptation.

Author information

1
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom.

Abstract

It has been proposed that growth cones navigating through gradients adapt to baseline concentrations of guidance cues. This adaptation process is poorly understood. Using the collapse assay, we show that adaptation in Xenopus laevis retinal growth cones to the guidance cues Sema3A or netrin-1 involves two processes: a fast, ligand-specific desensitization that occurs within 2 min of exposure and is dependent on endocytosis, and a slower, ligand-specific resensitization, which occurs within 5 min and is dependent upon protein synthesis. These two phases of adaptation allow retinal axons to adjust their range of sensitivity to specific guidance cues.

PMID:
15643427
PMCID:
PMC3682638
DOI:
10.1038/nn1380
[Indexed for MEDLINE]
Free PMC Article

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