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Arch Intern Med. 2005 Jan 10;165(1):113-7.

Coccidioidomycosis in patients with hematologic malignancies.

Author information

1
Division of Infectious Diseases, Mayo Clinic, Scottsdale, AZ 85259, USA. blair.janis@mayo.edu

Abstract

BACKGROUND:

An endemic fungal infection of the desert southwestern United States, coccidioidomycosis is generally a self-limited illness in healthy persons. Immunosuppressed persons who contract coccidioidomycosis, however, are at increased risk for disseminated infection.

METHODS:

We conducted a retrospective review of patients with coccidioidomycosis and hematologic malignancy or bone marrow disease.

RESULTS:

Fifty-five patients were identified. The most common underlying malignancies were non-Hodgkin lymphoma and chronic lymphocytic leukemia. Extrathoracic (or disseminated) infection was observed in 12 patients (22%). Fifteen patients (27%) died with active coccidioidomycosis. Treatment of the hematologic disease with corticosteroids or antineoplastic chemotherapy increased the risk of death.

CONCLUSION:

To date, this is the largest case series of patients with hematologic malignancy and coccidioidomycosis. In persons with hematologic malignancy, coccidioidomycosis can be a severe illness with a high risk for disseminated infection and death.

PMID:
15642886
DOI:
10.1001/archinte.165.1.113
[Indexed for MEDLINE]
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