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Clin Biochem. 2005 Feb;38(2):180-2.

Circulating pregnancy-associated plasma protein A is not an early marker of acute myocardial infarction.

Author information

1
Department of Cardiology, Coronary Care Unit, Hospital Universitario de Canarias, Ofra s/n La Cuesta E-38320, Tenerife, Spain. adrvdg@hotmail.com

Abstract

OBJECTIVE:

The purpose of this study was to assess whether serum levels of pregnancy-associated plasma protein A (PAPP-A) are elevated early in patients with acute myocardial infarction (AMI).

DESIGN AND METHODS:

We measured serum levels of PAPP-A in 80 patients with AMI and in 80 age-matched healthy control subjects. The mean (+/-SEM) time from onset of symptoms to blood sampling was 6.3 +/- 2.8 h in the group with AMI.

RESULTS:

The PAPP-A levels did not differ between the control group and the AMI group (1.24 +/- 0.07 vs. 1.29 +/- 0.02 mIU/l; P = 0.54).

CONCLUSIONS:

Measurement of serum PAPP-A does not seem to be a useful early marker for AMI.

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