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Arthritis Res Ther. 2005;7(1):42-3. Epub 2004 Dec 20.

Interleukin-7 deficiency in rheumatoid arthritis.

Author information

1
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. wjl@helix.nih.gov

Abstract

Interleukin-7 (IL-7) is a stromal factor that is crucial for the development of T lymphocytes in humans and mice, and also B lymphocytes in mice. IL-7 can act as a T cell growth factor as well as a critical anti-apoptotic survival factor. The essential non-redundant role of this cytokine for T cell development in vivo is indicated by the phenotype of murine knockout models as well as by humans with a T-B+NK+ form of severe combined immunodeficiency (SCID) resulting from mutations in IL-7 receptor alpha chain. IL-7 deficiency has now been found in patients with rheumatoid arthritis, a finding that relates not only to the T-lymphocyte status in this disease but also to the ability of patients with rheumatoid arthritis to recover from therapy-induced lymphopenia.

PMID:
15642153
PMCID:
PMC1064901
DOI:
10.1186/ar1492
[Indexed for MEDLINE]
Free PMC Article
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