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Am J Med Genet A. 2005 Feb 15;133A(1):18-22.

A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3.

Author information

1
Department of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan.

Abstract

A consanguineous family with autosomal recessive nonsyndromic hearing impairment (NSHI) was ascertained in Pakistan and displayed significant evidence of linkage to 3q13.31-q22.3. The novel locus (DFNB42) segregating in this kindred, maps to a 21.6 cM region according to a genetic map constructed using data from both the deCode and Marshfield genetic maps. This region of homozygosity is flanked by markers D3S1278 and D3S2453. A maximum multipoint LOD score of 3.72 was obtained at marker D3S4523. DFNB42 represents the third autosomal recessive NSHI locus to map to chromosome 3.

PMID:
15641023
PMCID:
PMC2909096
DOI:
10.1002/ajmg.a.30508
[Indexed for MEDLINE]
Free PMC Article

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