Format

Send to

Choose Destination
See comment in PubMed Commons below
Blood Purif. 2005;23(2):119-27. Epub 2005 Jan 6.

Mixed bacterial infection model of sepsis in rabbits and its application to evaluate superantigen-adsorbing device.

Author information

1
Specialty Material Research Laboratories, Toray Industries, Inc., Shiga, Japan.

Abstract

BACKGROUND:

Superantigens are suspected to be the potent and lethal pathogens of gram-positive sepsis, and a new therapy that targeted to superantigens are required.

METHODS:

A mixed infection model was developed in rabbits by the cecal ligation and puncture associated with the intraperitoneal injection of Staphylococcus aureus, which produces toxic shock syndrome toxin 1 (TSST-1). Animals were also hemoperfused with a superantigen-adsorbing device (SAAD), or a control column.

RESULTS:

The model animals revealed multiple organ failure and died 6-12 h after the injection of S. aureus. The plasma levels of TSST-1, but not of lipopolysaccharide (LPS), significantly (p < 0.01) and inversely correlated with mean arterial pressure (r = -0.63). Plasma TSST-1 level was significantly reduced and shock-onset time was significantly retarded in the SAAD treated group, although the survival time was not significantly affected.

CONCLUSIONS:

The animal model developed could serve as a model for sepsis. It is suggested that there is the potential application of SAAD in treating superantigen-related sepsis.

PMID:
15640604
DOI:
10.1159/000083206
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland
    Loading ...
    Support Center