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Postgrad Med J. 2005 Jan;81(951):1-6.

Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes.

Author information

1
Department of Endocrinology/Diabetes Centre, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands. m.tushuizen@vumc.nl

Abstract

The worldwide prevalence of type 2 diabetes mellitus has reached epidemic proportions. The so-called traditional risk factors cannot fully explain the excessive cardiovascular disease risk of type 2 diabetic patients. Numerous studies indicate that postprandial metabolic derangements, most notably hyperglycaemia and hypertriglyceridaemia, which are exaggerated and prolonged in type 2 diabetes, are important cardiovascular disease risk factors since they induce oxidative stress and endothelial dysfunctions. This review discusses the current evidence showing that postprandial dysmetabolism may indeed constitute an important cardiovascular disease risk factor as well as the mechanisms underlying this association. Finally, some possible therapeutic options and recommendations for future research are discussed.

PMID:
15640422
PMCID:
PMC1743184
DOI:
10.1136/pgmj.2004.020511
[Indexed for MEDLINE]
Free PMC Article
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